abstract：:Angioimmunoblastic T cell lymphoma (AITL) is characterized by the presence of atypical lymphocytes with clear cytoplasm and follicular dendritic cells, arborization of high endothelial blood vessels, and infiltration by inflammatory cells, such as epithelioid histiocytes, eosinophils, immunoblasts, and plasma cells. T...

journal_title：Pathology international

authors： Murakami Y,Shimada K,Kosugi H,Mori N

更新日期：2011-05-01 00:00:00

abstract：:Soluble receptor-resistant mutant 7 (ssr7) is isolated from a highly neurovirulent mouse hepatitis virus (MHV) JHMV cl-2 strain (cl-2). srr7 exhibits lower virulence than its maternal strain in infected mice, which is typically manifested in a longer lifespan. In this study, during the course of infection with srr7, s...

journal_title：Pathology international

authors： Kashiwazaki H,Nomura R,Matsuyama S,Taguchi F,Watanabe R

更新日期：2011-04-01 00:00:00

abstract：:Mucinous cystic neoplasm (MCN) of the pancreas is characterized by mucin-producing columnar epithelium and an ovarian-type stroma. It occurs almost exclusively in women and is almost always located in the pancreatic body or tail. Here, we report a case of large MCN located in the pancreatic head but not in the body no...

journal_title：Pathology international

authors： Naganuma S,Honda K,Noriki S,Kimura S,Murakami M,Koneri K,Katayama K,Yamaguchi A,Itoh H

更新日期：2011-01-01 00:00:00

abstract：:Patients with pulmonary small cell carcinoma are well known to have a poor prognosis. However, predictors of prognosis and treatment outcome have not been reported for this type of cancer. We examined whether excision repair cross-complementation group 1 (ERCC1), phosphorylated Akt (p-Akt), phosphorylated mammalian ta...

journal_title：Pathology international

authors： Ikeda S,Takabe K,Inagaki M,Suzuki K

更新日期：2010-11-01 00:00:00

abstract：:We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male. The patient initially experienced intermittent abdominal pain, and radiographic workup revealed an encapsulated retroperitoneal mass. A laparotomy was performed and the resected specimen represen...

journal_title：Pathology international

authors： Terado Y,Kurata A,Ishida T,Imamura T,Sakamoto A

更新日期：2010-10-01 00:00:00

abstract：:Intraductal tubulopapillary neoplasm (ITPN) has been recently reported in pancreas. We experienced an unusual intraductal growing bile duct tumor, which showed the same histopathologic and immunostaining profiles as ITPN of pancreas. A 72-year-old female patient visited hospital due to intrahepatic stone. The hilar bi...

journal_title：Pathology international

authors： Park HJ,Jang KT,Heo JS,Choi YL,Han J,Kim SH

更新日期：2010-09-01 00:00:00

abstract：:The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes. CXCR4 has also been found to be a prognostic marker in variou...

journal_title：Pathology international

authors： Furusato B,Mohamed A,Uhlén M,Rhim JS

更新日期：2010-07-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer predisposition syndrome, characterized by development of a variety of neoplasms in multiple organs. Central nervous system hemangioblastoma (CHB) is the most common manifestation of VHL disease. The germline mutations in the VHL tumor suppressor...

journal_title：Pathology international

authors： Zhou J,Wang J,Li N,Zhang X,Zhou H,Zhang R,Ma H,Zhou X

更新日期：2010-06-01 00:00:00

abstract：:Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as one of the most common genetic alterations in malignant mesotheliomas (MMs). Previous studies showed that this alteration might be useful for differentiating benign from malignant mesothelial tumors in cytology and surgical specimens. ...

journal_title：Pathology international

authors： Takeda M,Kasai T,Enomoto Y,Takano M,Morita K,Kadota E,Nonomura A

更新日期：2010-05-01 00:00:00

abstract：:Hepatic ultrasonic transient elastography (FibroScan) is a new diagnostic method for the assessment of hepatic fibrosis. There are limited data available on its use as a follow-up tool for patients with chronic hepatitis B. In this study, 134 patients were enrolled. Hepatic fibrosis was evaluated by liver stiffness me...

journal_title：Pathology international

authors： Zhang YG,Wang BE,Wang TL,Ou XJ

更新日期：2010-04-01 00:00:00

abstract：:Radiofrequency ablation (RFA) has become a widespread treatment option for liver carcinoma. There is limited knowledge regarding the macroscopic and histomorphological changes of induced lesions. Twelve domestic pigs underwent RFA using a Starburst XL device with ablation diameter of 3 cm. One animal died within 24 h,...

journal_title：Pathology international

authors： Kasper HU,Bangard C,Gossmann A,Dienes HP,Stippel DL

更新日期：2010-03-01 00:00:00

abstract：:Microscopic pulmonary tumor embolism is difficult to diagnose. Herein is presented the case of a patient who suffered from acute dyspnea and breast cancer on the right side. Two weeks after the breast cancer diagnosis the patient began to experience dyspnea. After 2 weeks of dyspnea, the patient died without an accura...

journal_title：Pathology international

authors： Kawasaki H,Ogura H,Arai Y,Baba S,Kosugi I,Tsutsui Y,Iwashita T

更新日期：2010-03-01 00:00:00

abstract：:The aim of the present study was to clarify protein profiling in small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC). The proteomic approach was used, and involved cell lysate from two cell lines (N231 derived from SCLC and LCN1 derived from LCNEC), with 2-D gel electrophoresis (...

journal_title：Pathology international

authors： Nagashio R,Sato Y,Matsumoto T,Kageyama T,Satoh Y,Ryuge S,Masuda N,Jiang SX,Okayasu I

更新日期：2010-02-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) is generally believed to be a marker of pulmonary manifestation of graft-versus-host disease (GVHD) in patients who have undergone bone marrow transplantation for hematological malignancy. Pulmonary manifestations reported as GVHD (other than BO) include lymphocytic bronchiolitis with cel...

journal_title：Pathology international

authors： Miyagawa-Hayashino A,Sonobe M,Kubo T,Yoshizawa A,Date H,Manabe T

更新日期：2010-02-01 00:00:00

abstract：:Teratoid Wilms' tumor is an unusual morphological entity characterized by a classic triphasic malignancy with predominantly heterologous tissue. The authors describe two cases of teratoid Wilms' tumor with an extrarenal site: one in a 13-year-old girl with vaginal spotting (patient 1) and another in a 1-day-old girl w...

journal_title：Pathology international

authors： Song JS,Kim IK,Kim YM,Khang SK,Kim KR,Lee Y

更新日期：2010-01-01 00:00:00

abstract：:The purpose of the present study was to determine whether the amount and the location of residual tumor are associated with outcome in surgically treated rectal cancer patients who receive preoperative chemoradiation therapy. Forty-three rectal cancer patients who underwent sphincter-saving operations after preoperati...

journal_title：Pathology international

authors： Kojima M,Ishii G,Yamane Y,Nishizawa Y,Saito N,Ochiai A

更新日期：2009-12-01 00:00:00

abstract：:Changes in cerebrospinal fluid (CSF) composition have been shown to accurately reflect pathological processes in the CNS, and are potential indicators of abnormal CNS states, such as tumor growth. To detect biomarkers in high-grade astrocytomas, the differential expression of proteins in the cerebrospinal fluid was an...

journal_title：Pathology international

authors： Ohnishi M,Matsumoto T,Nagashio R,Kageyama T,Utsuki S,Oka H,Okayasu I,Sato Y

更新日期：2009-11-01 00:00:00

abstract：:An asymptomatic 59-year-old man underwent pancreatoduodenectomy for a pancreatic mass that was discovered during a health check-up. Histopathology indicated typical features of lymphoplasmacytic sclerosing pancreatitis (LPSP) or autoimmune pancreatitis along with the presence of abundant IgG4-positive plasma cells thr...

journal_title：Pathology international

authors： Motosugi U,Ichikawa T,Yamaguchi H,Nakazawa T,Katoh R,Itakura J,Fujii H,Sato T,Araki T,Shimizu M

更新日期：2009-10-01 00:00:00

abstract：:Macrophage polarization is divided into M1 and M2 type based on membrane receptors, cytokines, and chemokines. M1 expresses CD80, interleukin (IL)-6, IL-12, and chemokine receptor (CCR)7, while M2 expresses CD163, IL10, and chemokine ligand (CCL)22. The aim of the present study was to identify the properties of infilt...

journal_title：Pathology international

authors： Nomura Y,Takeuchi M,Yoshida S,Sugita Y,Niino D,Kimura Y,Shimizu K,Aoki R,Suefuji N,Hirose S,Kikuchi M,Ohshima K

更新日期：2009-09-01 00:00:00

abstract：:A case of adenomatoid tumor of the pleura is reported, and its differential diagnosis from benign and malignant pleural lesions is discussed. A small pleural nodule was incidentally found during a thoracic operation in a 54-year-old woman with esophageal cancer. The patient had no history of exposure to asbestos, and ...

journal_title：Pathology international

authors： Minato H,Nojima T,Kurose N,Kinoshita E

更新日期：2009-08-01 00:00:00

abstract：:Cellular senescence is defined as irreversible cell arrest and could work as a safeguard against tumorigenesis. This mechanism was examined in chronic viral hepatitis-related hepatocarcinogenesis. By using surgical resected or wedge biopsied liver specimens from 87 chronic viral hepatitis patients in whom 35 neoplasti...

journal_title：Pathology international

authors： Ikeda H,Sasaki M,Sato Y,Harada K,Zen Y,Mitsui T,Nakanuma Y

更新日期：2009-07-01 00:00:00

abstract：:Hydatid cysts of the liver are known to occasionally rupture into the bile ducts and cause cholangitis. The histological features of this complication have not been adequately described in the literature. Herein is reported a case of severe eosinophilic cholangitis of the left hepatic lobe, occurring in a 24-year-old ...

journal_title：Pathology international

authors： Raptou G,Pliakos I,Hytiroglou P,Papavramidis S,Karkavelas G

更新日期：2009-06-01 00:00:00

abstract：:Microwave cell death (MCD) is unique in that microscopic morphology and antigenicity are well preserved, while enzymatic activity is lost. The aim of the present study was to carry out DNA electrophoresis, polymerase chain reaction (PCR) amplification and terminal deoxynucleotidyl transferase-mediated dUTP nick end-la...

journal_title：Pathology international

authors： Mori I,Ozaki T,Tabuse K,Utsunomiya H,Taniguchi E,Kakudo K

更新日期：2009-05-01 00:00:00

abstract：:Reported herein is a case of medulloblastoma with myogenic differentiation in a 3-year-old girl who died 1 year after appearance of clinical signs. Magnetic resonance imaging indicated a mass lesion in the cerebellar vermis. She underwent total resection of the tumor, followed by chemotherapy and radiotherapy in the b...

journal_title：Pathology international

authors： Kido M,Ueno M,Onodera M,Matsumoto K,Imai T,Haba R,Tamiya T,Huang CL,Sakamoto H

更新日期：2009-04-01 00:00:00

abstract：:Reported herein are seven cases of a histologically distinct oncocytic papillary renal cell carcinoma (OPRCC) with an inverted nuclear pattern. To define its prognostic significance, the clinicopathological features of OPRCC were compared to those of types 1 and 2 PRCC. The median age of the seven patients was 67 year...

journal_title：Pathology international

authors： Park BH,Ro JY,Park WS,Jee KJ,Kim K,Gong G,Cho YM

更新日期：2009-03-01 00:00:00

abstract：:This is the first report of segmental arterial mediolysis (SAM) accompanied with polyarteritis nodosa (PN), and manifesting aneurysms of the renal arteries. A 73-year-old woman was admitted to hospital because of a high fever. Laboratory tests showed leukocytosis with increased CRP level in the serum. Myeloperoxidase-...

journal_title：Pathology international

authors： Soga Y,Nose M,Arita N,Komori H,Miyazaki T,Maeda T,Furuya K

更新日期：2009-03-01 00:00:00

abstract：:Pilomyxoid astrocytoma, first described by Tihan et al., was recently included as an established variant of pilocytic astrocytoma in the World Health Organization classification of CNS tumors. Histologically, it much resembles pilocytic astrocytoma, but monomorphic myxoid tumor of pilocytic cells with prominent angioc...

journal_title：Pathology international

authors： Amatya VJ,Akazawa R,Sumimoto Y,Takeshima Y,Inai K

更新日期：2009-02-01 00:00:00

abstract：:Epithelioid angiomyolipoma (eAMLoma) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis (TSC). It is composed of polygonal large-sized tumor cells arranged in an epithelioid manner. Differential diagnosis from renal cell carcinoma (RCC) is often challen...

journal_title：Pathology international

authors： Kato I,Inayama Y,Yamanaka S,Ohshiro H,Gomi K,Shirai S,Aoki I,Uemura H,Miyoshi Y,Kubota Y,Yao M,Nagashima Y

更新日期：2009-01-01 00:00:00

abstract：:Metallothionein (MT) has been reported to play important physiological roles in the human body, but the distribution and significance of MT is not fully understood. In order to analyze MT expression, three kinds of polyclonal MT fragment antibodies were developed against NH2-terminal, middle regional and COOH-terminal...

journal_title：Pathology international

authors： Nakazato K,Nakajima K,Kusakabe T,Suzuki K,Nagamine T

更新日期：2008-12-01 00:00:00

abstract：:An intrathoracic mass was discovered on magnetic resonance imaging (MRI) of the spine in a 37-year-old Caucasian man with a 1 year history of progressively severe upper back pain. A subsequent chest CT scan indicated a 4 cm left hilar mass, extending to the apex and encasing a portion of the left bronchus and pulmonar...

journal_title：Pathology international

authors： Bahrami A,Allen TC,Cagle PT

更新日期：2008-11-01 00:00:00

abstract：:The clinical and pathological significance of intratumoral lymphangiogenesis (ITL) with human esophageal squamous cell carcinomas (ESCC) remains unclear, as does the role of signaling molecules such as vascular endothelial growth factor (VEGF)-A,C, platelet-derived growth factor (PDGF)-A, and p53, in the regulation of...

journal_title：Pathology international

authors： Inoue A,Moriya H,Katada N,Tanabe S,Kobayashi N,Watanabe M,Okayasu I,Ohbu M

更新日期：2008-10-01 00:00:00

abstract：:Herein is presented a case of carcinosarcoma of the pancreas in an 82-year-old woman, analyzed on immunohistochemistry and K-ras sequence. The tumor, which arose in the pancreas head, was removed on pancreaticoduodenectomy. The patient died, however, of disseminated intravascular coagulation syndrome from postoperativ...

journal_title：Pathology international

authors： Nakano T,Sonobe H,Usui T,Yamanaka K,Ishizuka T,Nishimura E,Hanazaki K

更新日期：2008-10-01 00:00:00

abstract：:Immunodeficient mice are widely used for xenografts of human cells and tissue. The purpose of the present study was to investigate the characteristics of xenograft human tumor models using engraftment of various non-hematopoietic tumors in the NOD/SCID/gamma(c) (null) mouse. For tumor models, human solid tumor tissues...

journal_title：Pathology international

authors： Fujii E,Suzuki M,Matsubara K,Watanabe M,Chen YJ,Adachi K,Ohnishi Y,Tanigawa M,Tsuchiya M,Tamaoki N

更新日期：2008-09-01 00:00:00

abstract：:Anomalous pancreaticobiliary junction (APBJ) is a congenital anomaly in which the pancreatic duct joins the common bile duct proximal to the sphincter of Oddi. Anatomical and immunohistochemical examination of the pancreas with APBJ has rarely been performed. A 72-year-old woman with gallbladder cancer and APBJ died o...

journal_title：Pathology international

authors： Tadokoro H,Takase M,Nobukawa B

更新日期：2008-08-01 00:00:00

abstract：:An association between autoimmune pancreatitis (AIP) and inflammatory abdominal aortic aneurysm (AAA) has never been reported. Reported herein is a case of IgG4-related inflammatory AAA accompanying metachronous AIP. A 77-year-old man presented with malaise and intermittent lower abdominal pain. Radiological examinati...

journal_title：Pathology international

authors： Ito H,Kaizaki Y,Noda Y,Fujii S,Yamamoto S

更新日期：2008-07-01 00:00:00

abstract：:Soft-tissue sarcomas can be divided into translocation-associated (TA) and non-TA sarcomas, the latter of which is often characterized by pleomorphic cytomorphology and aneuploidy. The aberrant expression of MAD2, an essential component of the mitotic spindle checkpoint, has been recently shown to promote aneuploidy. ...

journal_title：Pathology international

authors： Hisaoka M,Matsuyama A,Hashimoto H

更新日期：2008-06-01 00:00:00

abstract：:A case of gliosarcoma composed of glioblastoma and liposarcoma is presented. A 70-year-old Japanese man was admitted to hospital because of dysarthria and aphasia. Magnetic resonance imaging indicated a brain tumor located in the temporal-parietal area of the left hemisphere. He rejected any therapy and died of respir...

journal_title：Pathology international

authors： Fukuda T,Yasumichi K,Suzuki T

更新日期：2008-06-01 00:00:00

abstract：:Presented herein are two unusual epithelioid angiomyolipomas (AML) displaying prominent stromal sclerosis. Both patients were middle-aged women without a clinical history of tuberous sclerosis. One patient (case 1) had a 2 cm lesion arising in the renal cortex, and another (case 2) had a pararenal retroperitoneal tumo...

journal_title：Pathology international

authors： Matsuyama A,Hisaoka M,Ichikawa K,Fujimori T,Udo K,Uchihashi K,Aoki S,Hashimoto H

更新日期：2008-05-01 00:00:00

abstract：:A 79-year-old man presented with back pain. Chest CT scan showed elevated nodular lesions in the right parietal pleurae with pleural effusion. There were no intrapulmonary or mediastinal abnormalities. Under local anesthesia, right thoracoscopy and subsequent thoracoscopic pleural resection were performed using an ins...

journal_title：Pathology international

authors： Kawahara K,Sasada S,Nagano T,Suzuki H,Kobayashi M,Matsui K,Takata K,Yoshino T,Michida T,Iwasaki T

更新日期：2008-04-01 00:00:00

abstract：:According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC. Generally, nearly all PEComas have immunoreactivity for both melanocytic (HMB-45 and/or melan A)...

journal_title：Pathology international

authors： Adachi Y,Horie Y,Kitamura Y,Nakamura H,Taniguchi Y,Miwa K,Fujioka S,Nishimura M,Hayashi K

更新日期：2008-03-01 00:00:00